D-Mannose
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Chou ST, Lo HY, Li CC, et al. Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation. J Ethnopharmacol. 2016;194:617-625. doi:10.1016/j.jep.2016.10.059
Clare BA, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. 2009;15(8):929-934. doi:10.1089/acm.2008.0152
Díaz K, Espinoza L, Madrid A, Pizarro L, Chamy R. Isolation and Identification of Compounds from Bioactive Extracts of Taraxacum officinale Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents. Evid Based Complement Alternat Med. 2018;2018:2706417. Published 2018 Jan 1. doi:10.1155/2018/2706417
http://www.tahomaclinicblog.com/d-mannose-for-bladder-and-kidney-infections/
FASEB J. 2014 Apr;28(4):1854-69. doi: 10.1096/fj.13-245514. Epub 2014 Jan 13. Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice. Sharma V1, Nayak J, DeRossi C, Charbono A, Ichikawa M, Ng BG, Grajales-Esquivel E, Srivastava A, Wang L, He P, Scott DA, Russell J, Contreras E, Guess CM, Krajewski S, Del Rio-Tsonis K, Freeze HH.
Reid G, Bruce AW. Probiotics to prevent urinary tract infections: the rationale and evidence.World J Urol. 2006;24(1):28-32
Doron S, Gorbach SL. Probiotics: their role in the treatment and prevention of disease.Expert Rev Anti Infect Ther. 2006;4(2):261-75.
Hoesl CE, Altwein JE. The probiotic approach: an alternative treatment in urology. Eur Urol. 2005;47(3):288-96.
CoQ10 – 200 mg
Tian G, Sawashita J, Kubo H, Nishio SY, Hashimoto S, Suzuki N, Yoshimura H, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Mori M, Kitano M, Hosoe K, Takeda T, Usami S , Higuchi K. Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxidant Redox Signal. 2014 Jun 1;20(16):2606-20. doi: 10.1089/ars.2013.5406. Epub 2013 Dec 14. PMID: 24124769; PMCID: PMC4025630.
Vitamin D3 2000 IU (50 mcg), Vitamin D3 5000 IU (125 mcg)
Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S, Moreno L, Damsgaard CT, Michaelsen KF, Mølgaard C, Jorde R, Grimnes G, Moschonis G, Mavrogianni C, Manios Y, Thamm M, Mensink GB, Rabenberg M, Busch MA, Cox L, Meadows S, Goldberg G, Prentice A, Dekker JM, Nijpels G, Pilz S, Swart KM, van Schoor NM, Lips P, Eiriksdottir G, Gudnason V, Cotch MF, Koskinen S, Lamberg-Allardt C, Durazo-Arvizu RA, Sempos CT, Kiely M. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016 Apr;103(4):1033-44. doi: 10.3945/ajcn.115.120873. Epub 2016 Feb 10. PMID: 26864360; PMCID: PMC5527850.
LeBlanc ES, et al. Over-the-counter and compounded vitamin D: is potency what we expect? JAMA Intern Med. 2013 Apr 8;173(7):585-6.
GI Response
Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond). 2016 Apr 12;13:28. doi: 10.1186/s12986-016-0086-x. eCollection 2016.
Messing J, Niehues M, Shevtsova A, Borén T, Hensel A. Antiadhesive properties of arabinogalactan protein from ribes nigrum seeds against bacterial adhesion of Helicobacter pylori. Molecules. 2014 Mar 24;19(3):3696-717.
Kelly GS. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev. 1999 Apr;4(2):96-103.
Kim LS, Burkholder PM, Waters RF. Effects of low-dose larch arabinogalactan from larix occidentalis: a randomized, double-blind, placebo-controlled pilot study. Complement Health Pract Rev. 2002;7(3):221–9
Grieshop CM, Flickinger EA, Fahey GC., Jr Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs. J Nutr. 2002;132(3):478–82.
Vince AJ, McNeil NI, Wager JD, Wrong OM. The effect of lactulose, pectin, arabinogalactan and cellulose on the production of organic acids and metabolism of ammonia by intestinal bacteria in a faecal incubation system. Br J Nutr. 1990;63(01):17–26. doi: 10.1079/BJN19900088.
Babaee N1, Zabihi E, Mohseni S, Moghadamnia AA. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dent Res J (Isfahan). 2012 Jul;9(4):381-5.
Bhalang K, Thunyakitpisal P, Rungsirisatean Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. N. J Altern Complement Med. 2013 May;19(5):429-34.
Amirshahrokhi K, Bohlooli S, Chinifroush MM. The effect of methylsulfonylmethane on the experimental colitis in the rat. Toxicol Appl Pharmacol. 2011 Jun 15;253(3):197-202.
Hewlings S, Kalman DS. Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study. JMIR Res Protoc. 2018 Nov 29;7(11):e11139.
Flora Plus+, Flora and MegaFlora
Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial.BMJ. 2007 Jul 14;335(7610):80. Epub 2007 Jun 29.
D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002 Jun 8;324(7350):1361.
Armuzzi A, Cremonini F, Bartolozzi F, Canducci F, Candelli M, Ojetti V et al. The effect of oral administration of Lactobacillus GG on antibiotic-associated gastrointestinal side-effects during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther. 2001 Feb;15(2):163-9.
Cremonini F, Di Caro S, Nista EC, Bartolozzi F, Capelli G, Gasbarrini G et al. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2002 Aug;16(8):1461-7.
Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis. 2006 Jun;6(6):374-82.
Iva Hojsak. Probiotics in Children: What Is the Evidence? Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20(3): 139–146.