Chronic fatigue, digestive issues, irritated skin, yeast infections in the genitals, and intense sugar cravings. These are some of the problems that candida fungus and other fungi can cause if they are allowed to grow in the body.
Candida is a genus of yeast fungi that naturally exist in our gut flora. The most common is Candida albicans, which is found in the majority of healthy individuals. When present in normal quantities, it aids digestion. [1,2] However, if the gut flora is imbalanced, this opportunistic fungus can seize the chance to spread and become troublesome throughout the body.
Fungal infections affect over a billion people worldwide every year, and research suggests that this problem is only increasing. [3,4] These infections usually occur in the intestines and urinary or genital tract [5,6], but they can also manifest in the nose, ears, mouth, throat, nails, and skin—preferably where moisture is present.
In individuals with a normally functioning or moderately compromised immune system, candida infection is usually superficial and not dangerous, but it can be challenging to eradicate.
However, individuals with severely compromised immune systems may experience deeper candida infections that can become so widespread that they enter the bloodstream (sepsis) or affect vital organs such as the heart, lungs, or brain. This can cause severe symptoms, and in rare cases, such systemic infection can even lead to death. [7]
Why do people get candida?
There are many factors that can disrupt the balance of our microbiota. Overuse of antibiotics is a common cause, but the problem is also linked to stress and high consumption of sugar and junk food. Smoking and immunosuppressive drugs (such as cortisone) are other common causes of candida overgrowth. [8,9]
Yeast infections in the genitals are very common among women of childbearing age. Studies suggest that as many as 75 percent of all women may experience a yeast infection in their genitals at some point in their lives. [10] One reason for this may be fluctuating hormone levels, partly due to contraceptive pills and other forms of contraception, making women more susceptible. [11] Candida is also associated with digestive disorders such as IBS and certain allergic reactions. [12,13]
Asthma patients who inhale cortisone spray have a higher risk of candida infection in the throat and mouth. Therefore, it is important to rinse the mouth after each cortisone spray. If you have mild problems, you can try regularly gargling and/or rinsing the mouth with a little organic coconut oil or organic olive oil mixed with one or a couple of drops of essential oil of cloves. [14] You can also add a drop of Iosol iodine to the coconut oil before gargling. Remember that essential oil should not be swallowed but must be spit out.
Since yeast fungi like sugar, diabetics have a higher risk of developing candida overgrowth. As diabetics, they have higher sugar levels in the blood, but also in the mucous membranes and saliva [15]
Candida Syndrome - Candida Overgrowth
There is no doubt that candida infection (candidiasis) is a medical condition. However, there are also theories that one can suffer from a condition called candida syndrome - a chronic, low-grade overgrowth of Candida albicans that presents with nonspecific symptoms. These symptoms can include everything from chronic fatigue, irritated bowel, recurrent yeast infections, depression, brain fog, intense stress, strong cravings for sweets, food sensitivities, skin problems, and joint pain. In conventional medicine, this is not a recognized medical condition.
The originator of the idea of candida syndrome is the physician William Crook, who published the book "The Yeast Connection" in 1986. The book is partly based on the research of physician Orian Truss from 1978. According to Crook's theory, candida overgrowth in the intestines can lead to a deterioration of the intestinal mucosa's structure, allowing foreign particles that should pass through the intestine to enter the bloodstream and cause immune reactions in the body [16,17].
There is not much research on the connection between low-grade candida overgrowth and chronic health problems, but a few studies support a possible link to diseases such as IBS and chronic fatigue syndrome [18]. In particular, one study has shown that patients who met the criteria for candida syndrome significantly improved compared to a control group receiving placebo when treated with the antifungal medication nystatin [19].
Several doctors, including William Crook, have also published detailed reports on how the quality of life improves in patients treated for suspected candida syndrome [20,21].
Recently, there has been a research review on fungal overgrowth in the small intestine, a condition called SIFO (small intestinal fungal overgrowth). In the review, the authors go through two studies, both of which showed that just over a quarter of the participants, all of whom had unexplained gastrointestinal symptoms, suffered from SIFO [22]. This suggests that many people could have problems with low-grade fungal overgrowth, but it may be mistaken for something else or missed altogether.
According to another study, even the normal presence of yeast fungi in the intestine can worsen alcohol-related liver disease, which may mean that some conditions are more sensitive to yeast fungi than others [23].
How do you test for candida overgrowth?
Because the symptoms of candida overgrowth are so nonspecific, there is also a risk that candida overgrowth is used as a "catch-all diagnosis" for all sorts of problems, and that the real cause, which could be an overgrowth of bacteria in the small intestine (SIBO), parasitic infection, or inflammatory bowel diseases like Crohn's and ulcerative colitis, is missed.
Therefore, it is important to get to the bottom of the problem by testing. It is not enough to spit in a glass of water and see if the saliva "threads" when it sinks to the bottom, as some suggest.
There are stool tests that can track candida overgrowth. They can be ordered from specialized labs like Genova Diagnostics and BioHealth. The best thing to do is to contact a functional medicine doctor who can help you with the test and tailor a treatment plan. Email us at [email protected], and we will help you further with a candida protocol that you can try first.
You can also do an organic acids test (Great Plains Laboratory or Genova Organix Profile). This test is not used in conventional medicine and is considered controversial. However, a knowledgeable doctor or therapist can find it helpful, including the marker d-arabinitol, which can be a sign of fungal overgrowth. D-arabinitol is used as a marker in some hospitals to diagnose systemic candida infection [24].
How do you treat low-grade candida overgrowth?
Assuming you do not have severe problems with candida overgrowth that require medical care, you can try the following three steps to start with.
Step 1 – Change your diet to get rid of candida
High sugar and fast carbohydrates in the diet are linked to candida overgrowth in the vagina [25] and gastrointestinal tract [26]. There are also laboratory studies indicating that high sugar consumption weakens the immune response to candida [27]. Therefore, it is important to exclude sweets and eat a nutrient-dense diet, as poor nutrition is also a risk factor for both bacterial and fungal infections [28].
According to Traditional Chinese Medicine (TCM), fungal overgrowth is due to an excess of dampness and coldness in the body. Therefore, TCM recommends predominantly cooked, warm food and also foods classified as "warming." Other diets commonly recommended for fungal overgrowth include FODMAP, autoimmune protocol (AIP), and paleolithic (paleo) diets. A ketogenic diet is not recommended because too few carbohydrates unfortunately increase the risk of more aggressive candida.
If you suspect fungal overgrowth, there are many important dietary recommendations. Email us at [email protected] to receive a free candida protocol.
Step 2 – Kill the fungus
In this step, plant-based remedies, herbs, and nutrients with antimicrobial properties are used. There are many alternatives – here are some of the most common.
Berberine, an active compound found in goldenseal (Hydrastis canadensis). Studies of candida cultured in petri dishes (in vitro) show that berberine has a strong fungicidal effect.[30] Because berberine is so potent, herbal experts usually recommend short-term use, around 3–5 weeks, followed by a break of a couple of weeks. The same applies to extracts of other candida-inhibiting herbs like thyme [31] and oregano [32].
Lauric acid (or monolaurin) and caprylic acid, two fatty acids found in coconut and palm nuts. Coconut oil is also recommended, both internally and externally. In vitro studies of candida show that these fatty acids have a good fungicidal effect,[33] but research on humans is limited[34].
Undecylenic acid (undecylenic acid) found in Undecylenic Acid (SF722) is a monounsaturated fatty acid extracted from castor oil. It can help balance the intestinal flora and protect against fungal overgrowth.[35] An older study found it to be six times more effective against fungal overgrowth than caprylic acid.[36]
Clove in the form of oil extract has shown good effect against Candida albicans, including drug-resistant candida, both individually and in combination with antifungal drugs.[37]
Lactoferrin, a protein found in breast milk and saliva. It is usually taken from cows and has broad antibacterial and candida-inhibiting effects.[38]
Resveratrol found in Dr. Mercola's Purple Defense is a compound found in grape skin and pine bark. Several studies suggest that the compound has strong fungicidal properties, and one even suggests that resveratrol could be a safe and effective alternative to antifungal cream (clotrimazole) for external use.[39]
Tea tree oil. Animal studies suggest that oil from the Australian plant Melaleuca alternifolia has a good effect against vaginal candida infection,[40] and in the mouth (by gargling with a few drops of oil in water)[41]. Tea tree oil should not be swallowed as it can cause severe side effects such as vomiting, diarrhea, and hallucinations, but should only be used externally.[42] We also advise against the use of Tea Tree oil in the genitals.
Garlic extract can inhibit the formation of candida's so-called biofilm, which makes it easier for it to survive. This reduces the fungus's ability to develop resistance to drugs.[43] Garlic has also shown effectiveness against candida infection in the mouth and genitals.[44] According to a clinical study, a vaginal cream containing garlic and thyme was as effective as a vaginal cream containing the drug clotrimazole.[45]
Step 3 – Restore your gut flora to get rid of candida
The final step involves restoring a normal gut flora by slowly introducing fibres and probiotics.
Probiotic bacteria effective against candida infection include Saccharomyces boulardii, Lactobacillus rhamnosus, and Lactobacillus reuteri, among others. The latter two have shown particularly good efficacy in preventing unwelcome bacteria and fungi from establishing themselves.[46] Both strains are available in Flora Plus+. A Canadian study from 2001 showed that these strains restored and maintained a normal flora in the genitals of women after just one month of daily intake.[47]
In another study from 2020, 20 women with severe and chronic candida infection in the genitals were treated with a gel containing three different lactobacilli, including L. rhamnosus. The infection completely disappeared in 45 percent of the participants.[48] The strain is available in Flora Plus+.
Since an imbalanced gut flora promotes the growth of both candida and unwanted bacteria, it is important to maintain a healthy lifestyle. Continue to eat a balanced diet and avoid unnecessary stress to reduce the risk of candida overgrowth. Email our customer service for a free candida protocol.
Sources & scientific references
- Cheng SC, Joosten LA, Kullberg BJ, Netea MG. Interplay between Candida albicans and the mammalian innate host defense. Infect Immun. 2012;80(4):1304-1313.
- Douglas LM, Wang HX, Keppler-Ross S, Dean N, Konopka JB. Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans. MBio. 2011;3(1):00254-00211.
- Hsu JL, Ruoss SJ, Bower ND, Lin M, Holodniy M, Stevens DA. Crit Rev Microbiol. 2011;37(4):277-312.
- Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J Fungi (Basel). 2017 Oct 18;3(4):57.
- Kim J, Sudbery P. Candida albicans, a major human fungal pathogen. J Microbiol. 2011;49(2):171-177.
- Tampakakis E, Peleg AY, Mylonakis E. Interaction of Candida albicans with an intestinal pathogen, Salmonella entericaserovarTyphimurium.Eukaryot Cell. 2009;8(5):732-737.
- NIH. Systemic candidiasis. https://rarediseases.info.nih.gov/diseases/1076/systemic-candidiasis
- Hsu JL, Ruoss SJ, Bower ND, Lin M, Holodniy M, Stevens DA. Crit Rev Microbiol. 2011;37(4):277-312.
- Tani N, Rahnasto-Rilla M, Wittekindt C, et al. Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans. Eur J Med Chem. 2012;47(1):270-277.
- Sobel J, Candida vulvovaginitis. In: UpToDate, Barbieri R., Barss V. (Eds), UpToDate, Waltham, MA, 2012.
- Relloso M, Aragoneses-Fenoll L, Lasarte S, et al. Estradiol impairs the Th17 immune response against Candida albicans. J Leukoc Biol. 2012;91(1):159-165.
- Kumamoto CA. Inflammation and gastrointestinal Candida colonization.CurrOpinMicrobiol. 2011;14(4):386-391.
- Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol. 2005 Apr;20(2):106-11.
- Schulze J, Sonnenborn U. Yeasts in the gut: from commensals to infectious agents. DtschArztebl Int. 2009;106(51-52):837-842.
- Rodrigues CF, Rodrigues ME, Henriques M. Candida sp. J Clin Med. 2019 Jan 10;8(1):76
- Truss CO. Tissue Injury Induced By Candida Albicans Mental and Neurologic Manifestations. ORTHOMOLECULAR PSYCHIATRY, VOLUME 7, NUMBER 1, 1978, Pp. 17-37
- Schulze J, Sonnenborn U. Yeasts in the gut: from commensals to infectious agents. DtschArztebl Int. 2009;106(51-52):837-842.
- Berstad A, Hauso O, Berstad K, Berstad JER. From IBS to ME - The dysbiotic march hypothesis. Med Hypotheses. 2020 Feb 26;140:109648. doi: 10.1016/j.mehy.2020.109648. Epub ahead of print. PMID: 32126475.
- Evengård B, Gräns H, Wahlund E, Nord CE. Scand J Gastroenterol. 2007 Dec;42(12):1514-5.
- Gaby A. Nutritional Medicine. Concord, NH. Fritz Perlberg Publishing, 2011.
- Crook W.The Yeast Connection: A Medical Breakthrough. Vintage Books; Upd Rev Su edition (September 12, 1986)
- Erdogan A, Rao SS. Small intestinal fungal overgrowth. Curr Gastroenterol Rep. 2015 Apr;17(4):16.
- Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. J Clin Invest. 2017 Jun 30;127(7):2829-2841.
- Christensson B, Larsson L. Arabinitolkvot i urin ger tidig diagnostik av candidainfektion. Läkartidningen 48/2008.
- Donders GG, Bellen G, Mendling W. GynecolObstet Invest. 2010;70(4):306-321.
- Weig M, Werner E, Frosch M, Kasper H. Limited effect of refined carbohydrate dietary supplementation on colonization of the gastrointestinal tract of healthy subjects by Candida albicans.Am J ClinNutr. 1999;69(6):1170-1173.
- Man A, Ciurea CN, Pasaroiu D, Savin AI, Toma F, Sular F, Santacroce L, Mare A. An in vitro study. Mem Inst Oswaldo Cruz. 2017 Sep;112(9):587-592.
- Curtis L. Crit Care Med. 2010 Dec;38(12):2428-9; author reply 2429.
- Jeziorek M, Frej-Mądrzak M, Choroszy-Król I. The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs. Rocz Panstw Zakl Hig. 2019;70(2):195-200.
- da Silva AR, de Andrade Neto JB, da Silva CR, Campos Rde S, Costa Silva RA, Freitas DD, do Nascimento FB, de Andrade LN, Sampaio LS, Grangeiro TB, Magalhães HI, Cavalcanti BC, de Moraes MO, Nobre Júnior HV. Berberine Antifungal Activity in Fluconazole-Resistant Pathogenic Yeasts: Action Mechanism Evaluated by Flow Cytometry and Biofilm Growth Inhibition in Candida spp. Antimicrob Agents Chemother. 2016 May 23;60(6):3551-7.
- Jafri H, Ahmad I. Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis. J Mycol Med. 2020 Apr;30(1):100911.
- Bhat V, Sharma SM, Shetty V, Shastry CS, Rao CV, Shenoy S, Saha S, Balaji S. Contemp Clin Dent. 2018 Jun;9(Suppl 1):S3-S10.
- Bhattacharyya A, Sinha M, Singh H, Patel RS, Ghosh S, Sardana K, Ghosh S, Sengupta S. Mechanistic Insight Into the Antifungal Effects of a Fatty Acid Derivative Against Drug-Resistant Fungal Infections. Front Microbiol. 2020 Sep 8;11:2116.
- Omura Y, O'Young B, Jones M, Pallos A, Duvvi H, Shimotsuura Y. AcupunctElectrother Res. 2011;36(1-2):19-64.
- Shi D, Zhao Y, Yan H, Fu H, Shen Y, Lu G, Mei H, Qiu Y, Li D, Liu W. Antifungal effects of undecylenic acid on the biofilm formation of Candida albicans. Int J Clin Pharmacol Ther. 2016 May;54(5):343-53.
- Thorne Research. Undecylenic Acid. Alternative Medicine Review. 2002;7(1):68-70.
- Khan MS, Malik A, Ahmad I. Anti-candidal activity of essential oils alone and in combination with amphotericin B or fluconazole against multi-drug resistant isolates of Candida albicans. Med Mycol. 2012;50(1):33-42.
- Huang F, Song Y, Chen W, Liu Q, Wang Q, Liu W, Wang X, Wang W. Effects of Candida albicans infection on defense effector secretion by human oral mucosal epithelial cells. Arch Oral Biol. 2019 Jul;103:55-61.
- Shevelev AB, La Porta N, Isakova EP, Martens S, Biryukova YK, Belous AS, Sivokhin DA, Trubnikova EV, Zylkova MV, Belyakova AV, Smirnova MS, Deryabina YI. Pathogens. 2020 Apr 17;9(4):296.
- Mondello F, De Bernardis F, Girolamo A, Cassone A, Salvatore G. In vivo activity of terpinen-4-ol, the main bioactive component of MelaleucaalternifoliaCheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species. BMC Infect Dis. 2006;6:158.
- Willcox M. An evaluation of tea tree oil as an alternative microbicide.Nurs Times. 2005;101(11):32-33.
- Larson D, Jacob SE. Tea tree oil. Dermatitis. 2012;23(1):48-49.
- Khodavandi A, Harmal NS, Alizadeh F, et al. Comparison between allicin and fluconazole in Candida albicans biofilm inhibition and in suppression of HWP1 gene expression. Phytomedicine. 2011;19(1):56-63.
- Chung I, Kwon SH, Shim ST, Kyung KH. Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. J Food Sci. 2007;72(9):M437-440.
- Bahadoran P, Rokni FK, Fahami F. Iran J Nurs Midwifery Res. 2010;15(Suppl 1):343-349.
- Reid G, Dols J, Miller W. CurrOpinClinNutrMetab Care. 2009 Nov;12(6):583-7.
- Reid G, Beuerman D, Heinemann C, Bruce AW. FEMS Immunol Med Microbiol. 2001 Dec;32(1):37-41
- Donders G, Bellen G, Oerlemans E, Claes I, Ruban K, Henkens T, Kiekens F, Lebeer S. The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study. Eur J Clin Microbiol Infect Dis. 2020 Aug;39(8):1551-1558. doi: 10.1007/s10096-020-03868-x. Epub 2020 Apr 30.
Contact our customer service at [email protected] to receive free dietary advice as well as other complimentary self-care tips and health protocols if you are suffering from candida or other fungal issues. Our self-care protocols should not be used to diagnose, treat, or cure diseases. They are advice and tips for self-care that do not replace conventional medical care. Our protocols are intended for adults only. Food supplements should not be used as a substitute for a varied diet. It is important to maintain a diverse and balanced diet and a healthy lifestyle.